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chir98014  (Tocris)


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    Structured Review

    Tocris chir98014
    Chir98014, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 21 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/chir+98014/CHIR+98014/us12478645-84-4-13
    Average 93 stars, based on 21 article reviews
    chir98014 - by Bioz Stars, 2026-09
    93/100 stars

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    Related Articles

    other:

    Article Title: Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ
    Article Snippet: The GSK-3 inhibitors TWS 119, CHIR 98014, SB216763, LY2090314, IM-12, CHIR-99021 were purchased from MedChemExpress, Selleckchem (Houston, TX, US) or Tocris Bioscience (Bristol, UK).

    Article Title: Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons
    Article Snippet: Cells were treated with differentiation media containing E6 media, 0.5 μM CHIR-98014, 2 μM A83-01, 1 μM DBZ (Tocris, cat no. 4489/10) and 25 nM PD173074 (Tocris, cat no. 3044/10) for further 11 days.

    Article Title: Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification.
    Article Snippet: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Molecular and Integrative Physiology, University of Illinois at Urbana, Urbana, Illinois, USA Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Article Title: Nociceptor-immune interactomes reveal insult-specific immune signatures of pain
    Article Snippet: Cells were then replated at 5.5 M cells per well in six-well AggreWell plates (Stem Cell Technologies) and further differentiated for 11 days in E6 medium containing 0.5 μM CHIR-98014, 2 μM A83-01, 1 μM DBZ (Tocris, cat. no. 4489/10) and 25 nM PD173074 (Tocris, cat. no. 3044/10).

    Article Title: Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons.
    Article Snippet: Cells were treated with differentiation media containing E6 media, 0.5 μM CHIR-98014, 2 μM A83-01, 1 μM DBZ (Tocris, cat no. 4489/10) and 25 nM PD173074 (Tocris, cat no. 3044/10) for further 11 days.

    Article Title: Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons
    Article Snippet: Cells were treated with differentiation media containing E6 media, 0.5 μM CHIR-98014, 2 μM A83-01, 1 μM DBZ (Tocris, cat no. 4489/10) and 25 nM PD173074 (Tocris, cat no. 3044/10) for further 11 days.

    Article Title: Nociceptor-immune interactomes reveal insult-specific immune signatures of pain.
    Article Snippet: Cells were then replated at 5.5 M cells per well in six-well AggreWell plates (Stem Cell Technologies) and further differentiated for 11 days in E6 medium containing 0.5 μM CHIR-98014, 2 μM A83-01, 1 μM DBZ (Tocris, cat. no. 4489/10) and 25 nM PD173074 (Tocris, cat. no. 3044/10).

    Inhibition:

    Article Title: Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway
    Article Snippet: For lysosome inhibition experiments, cells were treated with 50 μM leupeptin (Sigma # L2884) and 10 mM NH 4 Cl (Sigma # A9434) as described in ( ) for 6 h before harvesting. .. For GSK3α/β inhibition, cultures were treated with 1 to 2 μM CHIR 98014 (Tocris #6695) as described in ( ) for 4 h before harvesting. .. Plasmids used for transfection include the following: pcDNA 3.1, pEGFP-C3 (Clontech), pCMV-tdTomato, pRK5-myc-Arc (generously provided by Dr Paul Worley, Johns Hopkins University), pRK5-myc-Arc5KR, pRK5-myc-Arc S170A/T175A, pRK5-myc-Arc T368A, pRK5-myc-Arc T380A, pRK5-myc-Arc K92Q, pRK5-myc-Arc ΔC-terminal, pRK5-myc-Arc ΔCC, pRK5-myc-Arc ΔEB , pRK5-EGFP, pRK5-EGFP-tau (Addgene #46904), and pRK5-EGFP-tau P301L (Addgene #46908).



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